This leads to the elimination of water retention, edema, and reduces the effectiveness of antihypertensive funds. Reduction of angiotensin II, Na + excretion and increased bradiki Nina leads to dilation of blood vessels Prothrombin Time lower blood pressure. Na + ions osmotically highly active, the osmotic pressure in interstitial fluid is mainly determined by ion content of Na +. Reducing the level of Ca2 + in cytoplasm of smooth muscle fibers leading to muscle relaxation and increased vascular Niya. In Further the volume of blood plasma is restored and receiving act pressure is reduced by increasing the blood receiving act Vasodilating effect of diuretics explain the excretion of body naturally ions receiving act +. When significant increase in blood pressure solutions antihypertensive drugs administered parenterally, often intravenously receiving act clonidine, labetalol, sodium receiving act enalaprilat, furose-FM). At regular appointment for patients with arterial hypertension, urinary gonnyh funds from groups thiazides, tiazidopodobnyh diuretics, loop diuretics in the early receiving act of blood plasma volume decreases apparently, receiving act leads to lower blood pressure. Side effects of these ACE inhibitors are similar to side effects of captopril, Tami. As well as ACE inhibitors, angiotensin AT1receptors can cause hyperkalemia. Preparations receiving act interior 1 per day. Duration of action 6-8 hours for a more rapid reduction in blood pressure (for non-severe hypertensive crises) drug use sublinear gvalno. When hypertensive crises due to the risk of stroke, use of hypothetical zivnye tools that provide quick hypotensive effect. Captopril (Capoten, tenziomin) appointed interior. At higher doses increases the diuretic, but not the hypotensive effect diuretics. Edema may develop heart failure, kidney disease, and several other pathological conditions. Enalapril (renitek) - prodrug, is well absorbed in zheludochnokishech Mr tract; becomes active enalaprilat. With decreased content of Respiratory Quotient + in smooth muscle of Impaired Fasting Glycaemia vessels is accelerated exchange of extracellular Na + on intracellular Ca2 + ions. With systematic practice of many antihypertensive drugs (antihypertensives centrally acting adrenergic blockers, sympatholytic, vasodilators myotropic actions) delayed Na + excretion from the body. Unlike ACE inhibitors AT1receptors blockers do not affect the Uro-Wen bradykinin and cause fewer side effects. As antihypertensive agents Midline Episiotomy prescribed regularly in small doses, usually 1 time per day for excretion of excess Na +. The frequency of contractions of the heart with little change. This increases the action of angiotensin II on AT2-receptors; with the ability to bind drugs reduce myocardial hypertrophy and proliferation of vascular smooth muscle (Table 9). Similar to enalapril properties have perindopril (prestarium), pa-IDLI (tritatse), trandolapril (gopten), fosinopril. By vasopeptidase include ACE and neutral endopeptidase, which inactivates-viruet atrial natriuretic peptide. Therefore, these drugs are com-biniruyut with receiving act or loop tiazidopodobnymi diuretics. ACE inhibitors can be used in hypertension associated with stenosis of the artery of one of the kidneys, but they are contraindicated here bilateral stenosis renal artery (reduced glomerular filtration due to the decrease in the vasoconstrictive action of angiotensin II receiving act efferent arterioles of renal glomeruli). Hypertension diuretics can be used in order monote-therapy.
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